Immunopathology of adipose tissue during metabolic syndrome
نویسندگان
چکیده
منابع مشابه
Immunopathology of Adipose Tissue during Metabolic Syndrome.
Excess energy intake and a sedentary lifestyle have led to increasing incidence of obesity which is a major risk factor for the development of insulin resistance. Research in the last two decades has revealed that chronic-low grade inflammation in adipose tissue is a key link between obesity and insulin resistance. As a result, adipose tissue is now considered an active immune organ with a key ...
متن کاملinflammation in metabolic syndrome: role of adipose tissue
metabolic syndrome is a chronic low-grade inflammation condition which is associated with central obesity, dyslipidemia, insulin resistance and hypertension. inflammation in metabolic syndrome is not only associated with elevated serum inflammatory markers, such as c-reactive protein (crp), but also, is associated with low-grade inflammation in adipose tissue and releasing of adipokines. higher...
متن کاملAdipose Tissue Dysfunction in Nascent Metabolic Syndrome
The metabolic syndrome (MetS) confers an increased risk for both type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Moreover, studies on adipose tissue biology in nascent MetS uncomplicated by T2DM and/or CVD are scanty. Recently, we demonstrated that adipose tissue dysregulation and aberrant adipokine secretion contribute towards the syndrome's low-grade chronic proinflammatory ...
متن کاملChagas disease, adipose tissue and the metabolic syndrome.
Trypanosoma cruzi infection of the adipose tissue of mice triggers the local expression of inflammatory mediators and a reduction in the expression of the adipokine adiponectin. T. cruzi can be detected in adipose tissue by PCR 300 days post-infection. Infection of cultured adipocytes results in increased expression of cytokines and chemokines and a reduction in the expression of adiponectin an...
متن کاملAdipose tissue expandability, lipotoxicity and the metabolic syndrome.
E‐mail: [email protected] Whereas it is clear that obesity is a cardiovascular risk factor, the mechanisms linking expansion of the adipose tissue (AT) to these co-morbilities is uncertain. We think that inappropriate AT expandability and function is a key determinant of obesity-associated metabolic complications by initiating a lipotoxic proinflammatory cascade that affects essential metabolic o...
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ژورنال
عنوان ژورنال: Turkish Journal of Pathology
سال: 2015
ISSN: 1018-5615,1309-5730
DOI: 10.5146/tjpath.2015.01323